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Anti-Nuclear Antibodies (ANA) Blot

Anti-Nuclear Antibodies (ANA) Blot

ANA are sensitive markers of SLE and other connective tissue disorders. Precise identification of their molecular specificities is essential as they may be associated with a particular disease or a disease subset. The ImmuBlot™ ANA Western Blot contains nuclear and cytoplasmic antigens from a HeLa cell line, which are separated according to their molecular weight (MW) by polyacrylamide gel electrophoresis and transferred onto a PVDF membrane.

 

Products Available

Code Product Description Determinations Product Insert
1170 ANA Blot 20

 

 

 

 

 

 

Prevalence of each Type of ANA in Disease

Antigen Disease Specificity Prevalence Molecular Weight
Sm SLE 75-95% B1 29 kD, B 28 kD,
      and 16 kD
U-1 RNP SLE 35-45% 68 kD, 34 kD, 22kD
  MCTD 95-98% 68 kD
SS-A/Ro SLE 25-35% 60 kD, 52 kD
  Sjogren's Syndrome 50-60%  
SS-B/La SLE 10-21% 48 kD, 43 kD
  Sjogren's Syndrome 40-50%  
Scl-70 Systemic Sclerosis 20-25% 100 kD
Jo-1 Myositis 20-25% 56 kD
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