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Anti-Neutrophil Cytoplasmic Antibodies (ANCA)

Atypical pANCA have been reported to occur in patients with IBD and primary sclerosing cholangitis (PSC). Studies have shown that ~80% of patients with UC and PSC and ~25% of patients with Crohn’s disease have pANCA.

Bacterial permealizing increasing factor (BPI) is one of the antigens associated with a pANCA reaction in patients with ulcerative colitis.


Atypical pANCA

Products Available

Code Product Description Determinations Product Insert
  non-CE CE
Immunofluorescence Kits
1116 ANCA (ethanol fixed) 4x6 well kit 24
1140 ANCA (ethanol fixed) 8x6 well kit 48
1141 p-ANCA (formalin fixed) 8x6 well kit
 48
1142 ANCA COMVI (Ethanol/Formalin fixed slides with c and pANCA controls) 48
ELISA Kits
1155 BPI 96 N/A
Components
2189 COMVI (c & p) ANCA 6 well slide
 6 well N/A N/A
2162 ANCA (ethanol fixed) 6 well slide 6 well N/A N/A
2186 p-ANCA (formalin fixed) 6 well slide
 6 well N/A N/A
2252 cANCA Positive Control 0.5 ml N/A N/A
2240 pANCA Positive Control 0.5 ml N/A N/A
2200 Negative Control 0.5 ml N/A N/A
2100 IgG Conjugate 5.0 ml N/A N/A

 

Anti-Saccharomyces Cerevisiæ Antibodies (ASCA)

Differentiation of Crohn’s Disease (CD) and Ulcerative Colitis (UC) can be problematic clinically. ASCA and ANCA studies are useful in screening tests for inflammatory bowel disorders in differentiating UC from CD and in proper identification of patients with indeterminate colitis.

The staining pattern of ANCA in IBD is atypical pANCA. The prevalence of pANCA in UC is 50- 80% while in CD the prevalence is 10-20%. In contrast, ASCA occur primarily in CD (50-60%) and rarely in UC.

Products Available

Code Product Description Determinations Product Insert
  non-CE CE
ELISA Kits
1156A ASCA IgA 96 N/A
1156G ASCA IgG 96 N/A
North America: 800.537.8378 | International: 716.691.0091 | Fax 716.691.0466
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