<20 APS Negative
=>20 APS Positive - Risk factor for thrombosis
<16 GPS Negative
=>16 GPS Positive - Risk factor for thrombosis and pregnancy loss
<22 MPS Negative
=>22 MPS Positive - Risk factor for thrombosis and pregnancy loss
|CPT Code||86148 (x3)
|Schedule Turnaround Time||Assay performed weekly. Report availability is within one week from the
time of specimen receipt.
|Specimen Requirements||Specimen need not be refrigerated or frozen. Collect 5-10 ml of blood in a red top or serum separator tube. If possible, separate serum from clot and place into orange tube provided with IMMCO collection kits. Do not puncture top of orange tube. If separation facilities are not available, the blood can be sent in the tube used for collection.
|Sample Stability||Sample is stable at ambient temperature during shipment. If sample is stored prior to shipment, it is stable refrigerated (2-8°C) up to five days and frozen (-20°C or lower) up to one year.
|Clinical Relevance||Anti-phospholipid antibodies are a heterogeneous group of immunoglobulins that bind to several anionic
phospholipids, including cardiolipin and phosphatidylserine. High serum levels of antiphospholipidantibodies
are frequently detected in patients with autoimmune (i.e., SLE) and nonautoimmunediseases,
as well as in apparently healthy individuals. These antibodies have been associated
with an increased risk for recurrent arterial and venous thrombotic events, thrombocytopenia and fetal loss.
These manifestations are the main features of the anti-phospholipid syndrome .Anti-phospholipid antibodies
are detected by either ELISAs using cardiolipin as the antigen (anti-cardiolipinantibodies) or coagulation
assays (lupus anticoagulants). Unlike cardiolipin, phosphatidylserine is a more physiologically relevant
phospholipid due to its presence in cell membranes of endothelial cells and
- Anti-Phospholipid/Cardiolipin Antibodies (APL)
- Antiphospholipid Syndrome
- Cardiovascular Disease
- Systemic Lupus Erythematosus (SLE)